Which of the following is a characteristic of anti-i?

Which of the following is a characteristic of anti-i?

• A. Associated with warm autoimmune hemolytic anemia
• B. Found in the serum of patients with infectious mononucleosis
• C. Detected at lower temperatures in the serum of normal individuals
• D. Found only in the serum of group O individuals

Answer: (B)

Anti-i is known for its association with infectious mononucleosis, where it can be present in significant amounts in the serum of affected individuals. This specific characteristic is related to the immune response generated against the i antigen, which is a carbohydrate structure found on the surface of red blood cells. The presence of anti-i can occur following infection with Epstein-Barr Virus (EBV), which causes infectious mononucleosis, leading to the production of this antibody. In contrast, while anti-i can be associated with conditions such as warm autoimmune hemolytic anemia, this is not its primary characteristic. The characteristic of being detected at lower temperatures is typically more relevant to other antibodies, like anti-I, which reacts optimally at lower temperatures, rather than anti-i. Lastly, the notion that anti-i is found only in the serum of group O individuals is incorrect, as this antibody can be present in individuals with other blood types as well. Thus, the link between anti-i and infectious mononucleosis clearly identifies the correct answer based on its clinical context.

Anti-i is known for its association with infectious mononucleosis, where it can be present in significant amounts in the serum of affected individuals. This specific characteristic is related to the immune response generated against the i antigen, which is a carbohydrate structure found on the surface of red blood cells. The presence of anti-i can occur following infection with Epstein-Barr Virus (EBV), which causes infectious mononucleosis, leading to the production of this antibody.

In contrast, while anti-i can be associated with conditions such as warm autoimmune hemolytic anemia, this is not its primary characteristic. The characteristic of being detected at lower temperatures is typically more relevant to other antibodies, like anti-I, which reacts optimally at lower temperatures, rather than anti-i. Lastly, the notion that anti-i is found only in the serum of group O individuals is incorrect, as this antibody can be present in individuals with other blood types as well. Thus, the link between anti-i and infectious mononucleosis clearly identifies the correct answer based on its clinical context.